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TermFinder - an online dictionary for students

knockout

(genetic biology)

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  • Grammar: noun
  • Definition: deletion or mutation of a gene in the genome to generate a mutant organism.
  • Example:
    1. The knockout of 8-10 homeobox genes in insects leads to loss of segmental specialisation.

    2. A knockout mouse is a genetically engineered mouse, where one or more of the genes have been made inoperable.
  • Related Compound: knockout gene, knockout experiment, knockout mouse


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